The teams will meet Thursday in Buffalo, N.Y.
The game will give the Orange (27-5) a chance to reverse their late-season fade. They were 25-0 and No. 1 in the country last month, but lost four of six to close the regular season then fell to North Carolina State in the Atlantic Coast Conference tournament quarterfinals.
Syracuse reached the Final Four last season, losing to national runner-up Michigan.
The Broncos (23-9) are in the field for the first time since 2004 after beating Toledo for the Mid-American Conference championship.