Gary Harris scored 17 points and Derrick Nix had 14 to help No. 8 Michigan State rout No. 4 Michigan 75-52 on Tuesday night, the rivalry's first matchup of top 10 teams.
The Spartans (21-4, 10-2 Big Ten) broke a first-place tie in the conference with No. 1 Indiana.
The Wolverines (21-4, 8-4) have lost three of four, but the closely contested setbacks on the road against the Hoosiers and Wisconsin were nothing like the latest.
Michigan State didn't trail once, led by as many as 16 points in the first half and enjoyed 30-point leads in the second half. The game was so lopsided that both coaches filled the court with reserves during the final minutes.
Trey Burke scored 18 points for the Wolverines.